Publications in Chronological Order and Hot Links:
Cumbay, M.G.and Watts, V.J. "Novel regulatory properties of human type 9 adenylate cyclase (AC9)" J. Pharmacol. Exp. Ther.310: 108-115, 2004
Click here for full text

Bradley, K.C., Mullins, A.J., Meisel, R.L. and Watts, V.J. "Sexual experience alters D1 receptor mediated cyclic AMP production in the nucleus accumbens of female syrian hamsters" Synapse 53:20-27, 2004.
Medline Abstract

Johnston, C.A., Beazely, M.A., Bilodeau, M.L., Andrisani, O., and Watts, V.J. " Differentiation-induced alterations in cyclic AMP signaling in the Cath.a differentiated (CAD) neuronal cell line." J. Neurochem. 88:1497-1508, 2004.
Medline Abstract

Jarrahian, A, Watts, V.J., and Barker, E.L. "D2 dopamine receptors modulate Ga-subunit coupling of the CB1 cannabinoid receptor" J. Pharmacol. Exp. Ther.308:880-886, 2004
Click here for full text

Vortherms, T.A. and Watts, V.J.Sensitization of neuronal A2A adenosine receptors following persistent D2 dopamine receptor activation" J. Pharmacol. Exp. Ther.308:221-227, 2004
Click here for full text

Lisinicchia, J.G., and Watts, V.J. "Sensitization of adenylate cyclase by short-term activation of 5-HT1A receptors" Cell. Signal. 15:1111-1117, 2003.
Text and Links

Johnston, C.A., and Watts, V.J. "Sensitization of adenylate cyclase: A general mechanism of neuroadaptation to persistent activation of Gi/o-coupled receptors?" Life Sci. 73:2913-2925, 2003.
Text + Links

Kurrasch-Orbaugh, D., Parrish, J.C., Watts, V.J., and Nichols D.E "A Complex Signaling Cascade Links the Serotonin2A Receptor to Phospholipase A2 Activation: The Involvement of MAP Kinases" J. Neurochem. . 86: 980-991, 2003.
Medline Abstract

Kurrasch-Orbaugh, D., Barker, E.L., Watts, V.J., and Nichols D.E "Serotonin 5-hydroxytryptamine 2A receptor-coupled phospholipase C and phospholipase A2 signaling pathways have different receptor reserves " J. Pharmacol. Exp. Therap. 304:229-237, 2003.
Click here for full text

Johnston, C.A., Beazely,M.A., Vancura, A.F., Wang, J.K.T., and Watts, V.J. "Heterologous sensitization of adenylate cyclase is PKA-dependent in CAD-D2L cells" J. Neurochem. . 82: 1087-96, 2002.
Medline Abstract

Watts, V.J "Molecular mechanisms for heterologous sensitization of adenylate cyclase". J. Pharmacol. Exp. Ther. 302:1-7, 2002.
Click here for full text

Watts, V.J., Taussig, R., Neve, R.L., and Neve, K.A. "Dopamine D2 receptor-induced heterologous sensitization of adenylyl cyclase requires Gs: characterization of Gs-insensitive mutants of adenylyl cyclase V ". Mol. Pharmacol. . 60:1168-1172, 2001.
Click here for full text

Neve, K.A., Cumbay, M.G., Thompson, K.R., Yang, R. Buck, D.C., Watts,V.J., DuRand, C.J., and Teeter, M.M. "Modeling and mutational analysis of a putative sodium-binding pocket on the dopamine D2 receptor". Mol. Pharmacol. 60:373-381, 2001.
Click here for full text

Johnston, C.A., Cumbay, M.G., Vortherms, T.A., and Watts,V.J. "Sensitization of adenylate cyclase in NS20Y-D2L cells by adrenoceptor activation of dopamine D2 receptors". FEBS Lett 497:85-89, 2001.
Click here for full text

Cumbay, M.G. and Watts,V.J."Heterologous sensitization of recombinant adenylate cyclases by activation of D2 dopamine receptors". J. Pharmacol. Exp. Ther. 297:1201-1209, 2001.
Click here for full text

Schutzer, W.E., Watts, V.J., Chapman, J. Cumbay, M.G., Neve, K.A., Neve, R.L., and Mader, S.L. "Viral-mediated gene delivery of constitutively activated Gs alters vasoreactivity". Clin. and Exp. Pharmacol. and Physio. 27:9-13, 2000.
Medline Abstract

Blair, J.B., Kurrasch-Orbaugh, D., Marona-Lewicka, D., Cumbay, M.G., Watts, V.J., Barker, E.L. and Nichols, D.E. "Effect of ring flourination on the pharmacology of hallucinogenic tryptamines". J. Med. Chem. 43:4701-4710, 2000.
Medline Abstract

Chapman, J. Schutzer, W.E., Watts, V.J., and Mader, S.L. "Impaired cholera toxin relaxation with age in rat aorta". J. Gerontol. 54:B154-B159, 1999.
Medline Abstract

Watts, V.J., Vu, M.N., Wiens, B.L., Jovanovic, V., Van Tol, H.H.M. and Neve, K.A. "Short- and long-term heterologous sensitization of adenylate cyclase by D4 dopamine receptors". Psychopharmacology 141:83-92, 1999.
Click here for link to full text (limited access)
Medline Abstract

Watts, V.J., Wiens, B.L., Cumbay, M.G., Vu, M.N., Neve, R.L., and Neve, K.A. "Selective Activation of Go by D2L Dopamine Receptors in NS20Y Neuroblastoma Cells". J. Neuroscience 18: 8692-8699, 1998.
SFN members click here for J. Neurosci. online
Medline Abstract

Lewis, M.M., Watts, V.J., Lawler, C.P., Nichols, D.E. and Mailman, R.B. "Homologous desensitization of the D1A dopamine receptor: Efficacy in causing desensitization dissociates from both receptor occupancy and functional potency". J. Pharmacol. Exp. Ther. 286:345-353, 1998.
Click here for full text

Watts, V.J. and Neve, K.A. "Activation of type II adenylate cyclase by D2 and D4 but not D3 dopamine receptors". Mol. Pharmacol.. 52:181-186, 1997.
Click here for full text

Watts, V.J. and Neve, K.A. "Sensitization of endogenous and recombinant adenylate cyclase by activation of D2 dopamine receptors". Mol. Pharmacol.. 50: 966-976, 1996.
Medline Abstract

Negash, K., Nichols, D.E., Watts, V.J., and Mailman, R.B. "Further definition of the D1 dopamine receptor pharmacophore: Synthesis of trans-6,6a,7,8,9,13b-hexahydro-5H-benzo[d]azepeines as rigid analogues of ß-phenyldopamine". J. Med. Chem. 40:2140-2147, 1997.
Medline Abstract

Ghosh, D. Snyder, S.E., Watts, V.J., Mailman, R.B., and Nichols, D.E. "8,9-Dihydoxy--2,3,7,11b tetra hydro-1H-naph[1,2,3-de] isoquinolone: a potent full dopamine D1 agonist containing a rigid ß-phenyl dopamine pharmacophore". J. Med. Chem. 39:549-555, 1996.
Medline Abstract

Mottola, D.M., Leiter, S., Tropsha, A., Watts, V.J., Wyrick, S.D., Nichols, D.E., and Mailman, R.B. "Conformational analysis of D1 dopamine receptor agonists: pharmacophore assessment and receptor mapping". J. Med. Chem. 39:285-296, 1996.
Medline Abstract

Watts, V.J., Lawler, C.P., Gonzales, A.J., Zhou, Q-Y., Civelli, O., Nichols, D.E., and Mailman, R.B. "Spare receptors and intrinsic activity: studies with D1 dopamine receptor agonists: the role of spare receptors". Synapse 21: 177-187, 1995.
Medline Abstract

Lawler, C.P., Gilmore, J.H., Watts, V.J., Walker, Q.D., Southerland, W.B., Cook, L.L., Mathis, C.A., and Mailman, R.B. "Interhemispheric modulation of dopamine receptor subtypes interactions in the unilateral 6-OHDA rodent model". Synapse 21:299-311, 1995.
Medline Abstact

Watts, V.J., Lawler, C.P., Neve, K.A., Nichols, D.E., and Mailman, R.B. "LSD and structural analogs: pharmacological evaluation at D1 dopamine receptors". Psychopharmacology 118:401-409, 1995.
Medline Abstract

Gilmore, J.H., Watts, V.J., Lawler, C.P., Nichols, D.E., and Mailman, R.B. "“Full” dopamine D1 agonists in human caudate: biochemical properties and therapeutic implications". Neuropharmacology 34:481-488, 1995.
Medline Abstract

Paterson, A., Boyer, J.L., Watts, V.J., Morris, A.J., Price, E.M., and Harden, T.K. "Concentration of enzyme dependent activation of PLC-ß1 and PLC -b2 by Ga11 and bg subunits". Cell. Signal. 7:709-720, 1995.
Medline Abstract

Knoerzer, T.A., Watts, V.J., Nichols, D.E., and Mailman, R.B. "Dopaminergic benzo[a]phenanthridines: resolution and pharmacological evaluation of the enantiomers of dihydrexidine, the full efficacy D1 dopamine receptor agonist.". J. Med. Chem. 38:3062-3070, 1995.
Medline Abstract

Snyder, S.E., Aviles-Garay, F.A., Chakraborti, R., Nichols, D.E., Watts, V.J., and Mailman, R.B. "Synthesis and evaluation of 6,7-dihydroxy-2,3,4,8,9,13b-hexahydro-lH-benzo[6,7]cyclohepta[1,2,3-ef][3]benzazepine, 6,7-dihydroxy-1,2,3,4,8,l2b-hexahydroanthr[10.4a,4-cd]azepine, and 10 aminomethyl-9,10-dihydro-1,2-dihydroxyanthracene as conformationally restricted analogues of b-phenyldopamine". J. Med. Chem. 38:2395-2409, 1995.
Medline Abstract

Brewster, W.K., Nichols, D.E., Watts, V.J., Riggs, R.M., Mottola, D.M., and Mailman, R.B. "Evaluation of Cis- and Trans-9- and 11-Hydroxy­-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridines as structurally rigid, selective D1 dopamine receptor ligands". J. Med. Chem. 38:318-327, 1995.
Medline Abstract

Minor, D.L., Wyrick, S.D., Charifson, P.S., Watts, V.J., Nichols, D.E., and Mailman, R.B. "Synthesis and molecular modeling of l-phenyl-1,2,3,4-tetrahydroisoquinolines and related 5,6,8,9-tetrahydro-13bH-dibenzo[a]quinolizines as D1 dopamine antagonists". J. Med. Chem. 37:4317-4328, 1994.
Medline Abstract

Knoerzer, T.A., Nichols, D.E., Brewster, W.K., Watts, V.J., Mottola, D.M., and Mailman, R.B. "Dopaminergic benzo[a]phenanthridines: resolution and pharmacological evaluation of the enantiomers of dihydrexidine, the full efficacy D1 dopamine receptor agonist". J. Med. Chem. 37:2453-2460, 1994.
Medline Abstract

Negash, K., Nichols, D.E., Watts, V.J., and Mailman, R.B."Synthesis of l-phenyl-2-amino-1,2,3,4-tetrahydronapthalene derivatives with dopamine D2 receptor affinity". Med. Chem. Res 5:33-42, 1994.

Watts, V.J., Lawler, C.P., Gilmore, J.H., Southerland, S.B., Nichols, D.E., and Mailman, R.B. "Dopamine D1 receptors: efficacy of full (dihydrexidine) vs. partial (SKF38393) agonists in primates vs. rodents". Eur. J. Pharmacol 242:165-172, 1993.
Medline Abstract

Watts, V.J., Lawler, C.P., Knoerzer, T., Mayleben, M.A., Neve, K.A., Nichols, D.E., and Mailman, R.B."Hexahydrobenzo[a]phenanthridines: Novel ligands for D3 dopamine receptors". Eur. J. Pharmacol. 239:271-273, 1993.
Medline Abstract

Lysle, D.T., Coussons, M.E., Watts, V.J., Bennett, E.H., and Dykstra, L.A. "Morphine-induced alterations of immune status: dose-dependency, compartment specificity, and antagonism by naltrexone". J. Pharamcol. Exp. Ther. 265:1071-1078, 1993.
Medline Abstract

Lysle, D.T., Coussons, M.E., Watts, V.J., Bennett, E.H., and Dykstra, L.A. "Morphine-induced modulation of immune status: evidence for opioid receptor mediation and compartment specificity". Adv. Exp. Bio. Med. 335:53-59, 1993.
Medline Abstract

Faulkner, T.P., Cantleberry, S.G., Watts, V.J., and Hussain, A.S. "Comparative pharmacokinetics of ethanol in inbred strains of mice using doses based on total body water". Alcoholism: Clin. Exp. Res. 14:82-86, 1990.
Medline Abstract

Home Page Research Other Links