phone: (765) 337-7699

Department of Pharmaceutical and Biomedical Sciences

Postdoctoral associate position and graduate research opportunities available in the areas of Biomaterials and Nanobiotechnology. Please contact Dr. Xu for detailed information.

Research Interests

The primary interests of our lab are design and synthesis of biomaterials, and exploring their biomedical applications.  The long-term goals of our research are to develop cancer targeted nano-sized drug carrier to eradicate cancer and to design novel drug formulation to alleviate central nervous system (CNS) diseases. Currently, our foci are rational design, and synthesis environment responsive polymers, and fabricating them into cancer or CNS targeted nanoparticle for chemotherapy or gene therapy.

EDUCATION

·         Purdue University, Postdoctoral Research Associate, 2007-2009 (Pharmaceutics)

·         University of Wyoming, Ph.D. 2007 (Chemical Engineering)

·         Beijing University of Chemical Technology, M.S. (Chemical Engineering)

·         Nanchang University, B.S. (Chemical Engineering)

AWARD

Outstanding Dissertation Award 2008

professional organizations

Sigma Xi

American Chemical Society

American Association of Pharmaceutical Scientists

PUBLICATIONS

Peer-reviewed Articles

1.  Ma H., Jones K.R., Guo R., Xu P., Shen Y., and Ren J., Cisplatin Compromises Myocardial Contractile Function and Mitochondrial Ultrastructure: Role of Endoplasmic Reticulum Stress. Clin Exp Pharmacol Physiol. (2009)  Accepted

2.  Xu, P. Quick G. and Yeo, Y., Gene delivery through the use of a hyaluronate-accociated intracellularly degradable crosslinked polyethyleneimine. Biomaterials. (2009) 30 (29):5834-43.

3.  Ma, H., Li, S., Xu, P., Babcock, S.A., Dolence, E.K., Brownlee, M., Li, J., and Ren, J., Advanced glycation endproduct (AGE) accumulation and AGE receptor (RAGE) upregulation contribute to the onset of diabetic cardiomyopathy. Journal of Cellular and Molecular Medicine in press doi:10.1111/j.1582-4934.2008.00547.x.

4.  Xu, P., Gullotti, E., Tong, L., Highley, C.B., Errabelli, D.R., Hasan, T., Cheng, J., Kohane, D.S_., and  Yeo, Y., Intracellular drug delivery by poly(lactic-co-glycolic acid) nanoparticles, revisited. Molecular Pharmaceutics (2009), 6(1), 190-201.

5.  Yang, Y., Bajaj, N., Xu, P., Ohn, K., Tsifansky, M., and Yeo, Y. Development of highly porous large PLGA microparticles for sustained local drug delivery to the lung. Biomaterials (2009), 30(10), 1947-53.

6.  Xu, P., Li, S., Li, Q., Van Kirk, E.A, Ren, J., Murdoch, W.J., Zhang, Z., Radosz, M., and Shen, Y. Virion-mimicking nanocapsules from pH-controlled hierarchical self-assembly for gene delivery. Angew Chem Int Ed. (2008), 47(7), 1260-1264.

7.  Shen, Y., Zhan Y., Tang J., Xu P., Johnson P.A., Radosz M., Van Kirk E.A., Murdoch, W.J. Multifunctioning pH-responsive nanoparticles from hierarchical self-assembly of polymer brush for cancer drug delivery. AIChE Journal (2008), 54 (11), 2979-2989.

8.  Turdi, S., Xu, P., Li, Q., Kerram, P., Shen, Y., and Ren, J., Amidization of doxorubicin alleviates doxorubicininduced cardiomyopathy. Toxicol. Lett. (2008), 178(3), 197-201

9.  Xu, P., Van, Kirk E.A., Zhan, Y., Murdoch, W.J., Radosz, M., and Shen, Y., Targeted charge-reversal nanoparticles for nuclear drug delivery. Angew Chem Int Ed. (2007), 46(26), 4999-5002.

10.Jin, W., Xu, P., Zhan, Y., Shen, Y., Van Kirk, E.A., Alexander, B., Murdoch, W.J., Liu, L., and Issak, D.D., Degradable cisplatin-releasing core-shell nanogels from zwitterionic poly(beta-aminoester)-graft-PEG for cancer chemotherapy. Drug Delivery. (2007), 14(5), 279-86.

11.Xu, P., Li, S., Li, Q., Ren, J., Van Kirk, E.A., Murdoch, W.J., Radosz, M., and Shen, Y., Biodegradable cationic polyester as an efficient carrier for gene delivery to neonatal cardiomyocytes. Biotechnology & Bioengineering (2006), 95(5), 893-903.

12.Xu, P., Van Kirk, Edward E.A., Murdoch, W.J., Zhan, Y., Isaak, Dale D., Radosz, M., and Shen, Y., Anticancer efficacies of cisplatin-releasing pH-responsive nanoparticles. Biomacromolecules (2006), 7(3), 829-835.

13.Xu, P., Van Kirk, E.A., Li, S., Murdoch, W.J., Ren, J., Hussain, M.D., Radosz, M., and Shen, Y., Highly stable core-surface-crosslinked nanoparticles as cisplatin carriers for cancer chemotherapy. Colloids and Surfaces, B: Biointerfaces (2006), 48(1), 50-57.

14.Xu, P., Tang, H., Li, S., Ren, J., Van Kirk, E.A., Murdoch, W.J., Radosz, M., and Shen, Y., Enhanced stability of core-surface cross-linked micelles fabricated from amphiphilic brush copolymers. Biomacromolecules (2004), 5(5), 1736-1744.

Patents

1.   Yeo, Y., and Xu, P., Non-viral gene delivery vector. Provisional patent application No. 61/058,057

2.   Shen, Y., and Xu, P.,   Charge reversible polymers. PCT/US2007/015447.

3.   Shen, Y., and Xu, P.,   Targeted charge-reversal nanoparticles for nuclear drug delivery. PCT/US2007/008146.

4.   Shen, Y., Radosz M., and Xu, P.,   Nanoparticles for cytoplasmic drug delivery to cancer cells. Provisional patent application No. 60/608,599

ABSTRACTS AND PRESENTATIONS

1.  Xu. P., Yeo, Y., Polyanion-Coated Intracellularly Degradable Nanoparticles as a Safe and Efficient Gene Delivery System. 35th Annual Meeting of the Controlled Release Society, New York, NY, (2008)

2.  Yeo, Y., Yang, Y., Bajaj, N., Xu, P., Development of Highly Porous PLGA Microparticles for Sustained Local Drug Delivery to the Lung. 35th Annual Meeting of the Controlled Release Society, New York, NY, (2008)

3.  Ma, H., Xu, P., Shen, Y., Ren, J., Cisplatin compromises the ultrastructure of mitochondria and mechanical func tion of cardiomyocytes. 2008 NISBRE, Washington DC, (2008)

4.  Xu, P., Van Kirk, E.A., Zhan, Y., Murdoch, W.J., Radosz, M., and Shen, Y., Targeted charge-reversal nanoparticles for nuclear drug delivery. 34th Annual Meeting of the Controlled Release Society, Long Beach, California, (2007)

5.  Xu, P., Zhan, Y., Van Kirk, E.A., Murdoch, W.J., and Shen, Y., Charge-reversal PAMAM dendrimer. 34th Annual Meeting of the Controlled Release Society, Long Beach, California, (2007).

6.  Xu, P., Zhan, Y., Li, S., Van Kirk, E.A., Ren, J., Murdoch, W.J., Radosz, M., and Shen, Y., Artificial virion nanocapsules for gene delivery. 34th Annual Meeting of the Controlled Release Society, Long Beach, California, (2007).

7.  Xu, P., Zhan, Y., Li, S., Van Kirk, E.A., Ren, J., Murdoch, W.J., Radosz, M., and Shen, Y., Layered nanoparticles for gene delivery. 232nd ACS National Meeting, San Francisco (2006).

8.  Xu, P., Li, S., Li, Q., Zhan, Y., Ren, J., Radosz, M., and Shen, Y., Polymeric artificial virus for gene delivery. 231st ACS National Meeting, Atlanta (2006).

9.  Zhan, Y., Van Kirk, E.A., Xu, P., Murdoch, W.J., Radosz, M., and Shen, Y., pH-responsive three layer onion-structured nanoparticles for drug delivery. 231st ACS National Meeting, Atlanta (2006).

10.Xu P., Li S., Li Q., Ren J., Shen Y., and Radosz M., Modified polymers as safe and efficient gene delivery carriers. 230th ACS National Meeting, Washington (2005).

11.Shen, Y., Xu, P., Li, S., Li, Q., Ren, J., Van Kirk, E.A., Murdoch, W.J., and Radosz, M., Biodegradable cationic polymers as efficient gene delivery carriers. 229th ACS National Meeting, San Diego (2005).

12.Xu, P., Tang, H., Li, S., Ren, J., Van Kirk, E.A., Murdoch, W.J., Radosz, M., and Shen, Y., Highly stable core-surface-crosslinked micelles as drug carriers for cancer chemotherapy. AIChE Annual Meeting, Austin (2004)

13.Xu, P., Van Kirk, E.A., Li, S., Ren, J., Murdoch, W.J., Radosz, M., and Shen, Y. Enhanced anticancer activity of core-surface-crosslinked nanoparticles. 228th ACS National Meeting, Philadelphia (2004).

14.Xu, P., Radosz, M., and Shen, Y., Pseudo "living" free radical copolymerization of methacrylic macromonomers. 228th ACS National Meeting, Philadelphia (2004).

15.Yang, X., Xu, P., Ding, S., Radosz, M., Shen, Y., Synthesis of 1-(4-vinylbenzyl)thymine and its polymerization by RAFT and ATRP techniques. 227th ACS National Meeting, Anaheim (2004).

16.Xu, P., Radosz, M., and Shen, Y., Core-surface crosslinked micelles fabricated from PCL/PEG brush copolymers. 227th ACS National Meeting, Anaheim (2004).

Manuscript reviews

Nanotechnology; Anti-Cancer drugs; Acta Biomaterialia; Biomedical Materials; Journal of Drug Targeting; Journal of Tissue Engineering and Regenerative Medicine.

Student supervision

HaeIn Yan (Pre-pharm, DURI 07F-08S); Griffin Quick (BME, DURI08); Jennifer Bastijanic (BME, DURI08); Tyler Shugg (Pre-pharm)